Accelerate performance for HPC and AI workloads

Four dual-slot GPU compute in 2U

ESC4000A-E12 is an AMD EPYC™ 9004 single-socket server built for the demands of enterprise AI infrastructure to deliver unprecedented performance with industry-leading GPUs, faster GPU interconnect and higher-bandwidth fabric, and supports up to four dual-slot active or passive GPUs scalable configuration with a choice of NVIDIA NVLink® Bridge or AMD Infinity Fabric™ Link to enable scaling of performance with increased bandwidth — ready to match your AI and HPC workloads.
  • AMD EPYC logo
  • NVIDIA certified logo
  • AMD Instinct logo
  • AMD Xilinx logo
ESC4000A-E12 server
System layout System layout

Rear PCIe Riser
1 x PCIe x16 slots (Gen5 x16 link, FH, HL)
1 x PCIe x16 slot (Gen5 x16/x8 link, FH, HL)
or OCP socket option
1 x PCIe x8 slot (Gen5 x0/x8 link, LP, HL)

12 x RDIMM DDR5 4800Mhz

1 x PCIe x8 slot
(Gen5 x8 link, LP, HL)
Only for SKU1

1+1 Redundant 2600W
Titanium CRPS-R

4 x PCIe x16 slots for dual-slot GPU cards (Gen5 x16 link, FH, FL)

1 x AMD EPYC 9004
processor (Up to 400W)

Front panel layout Front panel layout

1 x PCIe x8 slot (Gen5 x8 link, LP, HL)
Only for SKU1

1+1 Redundant 2600W Titanium CRPS-R

  • 2 x 2.5” & 4 x 3.5“ Hot-swap Storage Bays

  • SKU1:
    2 x 2.5” SATA/SAS*/NVMe +
    2 x 3.5” SATA/SAS*/NVMe +2 x 3.5” SATA/SAS*

  • SKU2:
    (Build to order, one PCIe x8 link will be occupied)
    2 x 2.5” SATA/SAS*/NVMe +
    4 x 3.5” SATA/SAS*/NVMe

* SAS support required a HBA/RAID card.
* For SKU1, additional 2 x NVMe support required a RAID card.

Rear panel layout

1 x PCIe x16 slot (Gen5 x16 link, FH, HL)
1 x PCIe x16 slot (Gen5 x16/x8 link, FH, HL)​ or OCP socket option
1 x PCIe x16 slot (Gen5 x0/x8 link, LP, HL)​

Comprehensive liquid-cooling solutions

Better data-center power efficiency

As liquid cooling is maturing in the age of supercomputing, ESC4000A-E12 is purpose-built for sustainability. ESC4000A-E12 supports liquid-cooled NVIDIA® A100 PCIe GPU that delivers powerful performance with less energy and provides direct-to-chip (D2C) cooling or immersion-cooling solutions for maximum data-center energy efficiency.
Learn more
  • the icon of Turnkey rack support for solutions with full installation and testing
    Turnkey rack support for solutions with full installation and testing
  • the icon of Server validated on selected liquid cooling solutions
    Server validated on selected liquid cooling solutions
  • the icon of Close partnerships with industry-leading cooling solution providers
    Close partnerships with industry-leading cooling solution providers

Optimized Thermal Design

Independent CPU and GPU airflow tunnels

Our servers features a streamlined design with dedicated CPU and GPU airflow tunnels for seriously efficient heat dissipation. This advanced design provides better cooling for both the GPU and CPU, enabling heat to be expelled into the surrounding ambient air for greater energy efficiency and overall savings on system power.
GPU and CPU Airflow tunnel
A close look at GPU fans

Titanium power supplies

Up to 96% efficient for operating cost reduction

ESC4000A-E12 supports 2600 W 80 PLUS® Titanium redundant power supplies to ensure power is supplied to the system equally from all power sources, maximizing efficiency and enabling uninterrupted operation.
The front/rear panel with four power supplies


Remote server management

ASUS ASMB11-iKVM is the latest server-management solution from ASUS, built upon the ASPEED 2600 chipset running on the latest AMI MegaRAC SP-X. The module provides various interfaces to enable out-of-band server management through WebGUI, Intelligent Platform Management Interface (IPMI) and Redfish® API.
Learn more
ASUS BMC boot time comparison

IT infrastructure-management software

Streamline IT operations via a single dashboard

ASUS Control Center (ACC) is remote IT-management software application designed for monitoring hardware and software IT assets and inventory status, and enabling seamless remote BIOS configurations and updates, efficient IT diagnostics and troubleshooting and enhanced security with hotfix updates — allowing easier server management for any IT infrastructure.
Learn more
ASUS Control Center software on desktop, tablet and mobile device

Hardware Root-of-Trust Solution

Detect, recover, boot and protect

ASUS servers integrate PFR FPGA as the platform Root-of-Trust solution for firmware resiliency to prevent from hackers from gaining access to infrastructure. ASUS security solutions are fully compliant with the 2018 National Institute of Standards and Technology (NIST) SP 800 193 specification.

* Platform Firmware Resilience (PFR) module must be specified at time of purchase and is factory-fitted. It is not for sale separately.

Trusted Platform Module 2.0

ASUS servers also include support Trusted Platform Module 2.0 (TPM 2.0) to secure hardware through integrated cryptographic keys and offer regular firmware update for vulnerabilities.
Learn More about the product support list


NVIDIA® solutions for 3D collaboration

NVIDIA Omniverse partnership
NVIDIA is dedicated to its partners and believes that a strong partnership is the foundation of mutual success.
NVIDIA Omniverse logo
Full ASUS product lineup for Omniverse Enterprise
ASUS has the world’s best PCs, servers, monitors and graphics cards. With an expanding range of superior content-creation and gaming products, ASUS leads the industry through innovation to create the most ubiquitous, intelligent productivity.
ASUS Omniverse product overview
Strong partnership with 3D partners
Connect to the top industry apps your teams use every day, with plug-ins that enable live-sync collaboration and iteration across multiple software suites simultaneously — all brought together in Omniverse Enterprise.
Omniverse partner logo set
Success cases
Reduce deployment risks with a complete suite of VMware data-center products for Omniverse Enterprise.
Mooshine XR studio logoReallusion logo


Improved IT operational efficiency

  • Tool-less cover

    Tool-less Cover

    ASUS servers feature three easy-access covers that can be opened without tools, enabling IT staff to perform maintenance on specific components without removing the server fully from the rack.

  • Front-bezel Q-Code

    Front-bezel Q-Code

    ASUS servers have a visible Q-Code/port-80 LED display LED for simple monitoring of the entire boot process, from power on through loading of the operating system.

  • Hot-swap design

    Hot-swap design

    ASUS servers feature multiple hot-swap components, including fans, power supplies and storage for easy troubleshooting to keep 24/7 seamless operations.


AMD EPYC™ 9004 Series Processors

The 9004 Series EPYC CPUs amplifies the AMD history of x86 architecture innovations and record-breaking performance with next generation 5nm technology as well as introducing support for high performant DDR5 DIMMs and fast PCIe® Gen 5 I/O. EPYC 9004 CPUs support 12 memory channels with 2 DIMMs/channel capability, delivering the resources needed for memory hungry AI, ML, HPC, and large in-memory computations.
  • Up to


    Zen 4c cores

  • Up to


    L3 Cache

    with AMD 3D V-Cache technology

  • 128

    (1 socket)

    PCIe 5.0

Learn more